2-[(7R,10S,13R,16R,19R,22S,25R)-25-amino-13-(4-aminobutyl)-7,22-dibenzyl-10-[(1R)-1-hydroxyethyl]-16,19-bis(1H-indol-3-ylmethyl)-6,9,12,15,18,21,24-heptaoxo-1,2-dithia-5,8,11,14,17,20,23-heptazacyclohexacos-5-yl]acetamide - Names and Identifiers
2-[(7R,10S,13R,16R,19R,22S,25R)-25-amino-13-(4-aminobutyl)-7,22-dibenzyl-10-[(1R)-1-hydroxyethyl]-16,19-bis(1H-indol-3-ylmethyl)-6,9,12,15,18,21,24-heptaoxo-1,2-dithia-5,8,11,14,17,20,23-heptazacyclohexacos-5-yl]acetamide - Risk and Safety
Chloro(2-methylphenyl)bis(triphenylphosphine)nickel(II) is an organic nickel compound with the formula Ni(C6H4CH3)(Cl)(PPh3)2. The following is a description of the properties, uses, preparation and safety information of this compound:
Nature:
-Appearance: Chloro(2-methylphenyl)bis(triphenylphosphine)nickel(II) is a yellow crystal.
-Melting point: about 170-174°C.
-Solubility: Soluble in common organic solvents such as ethanol, dimethylformamide, etc.
Use:
- Chloro(2-methylphenyl)bis(triphenylphosphine)nickel(II) is commonly used as a catalyst in organic synthesis, especially in cross-coupling reactions (such as Suzuki reactions) and cyclization reactions.
-Can also be used to synthesize organometallic compounds.
Preparation Method:
Chloro(2-methylphenyl)bis(triphenylphosphine)nickel(II) preparation method is relatively simple, a general method is as follows:
1. First, triphenylphosphine (PPh3) is reacted with iodobenzene (2-methylphenyl) to obtain diphenylphosphine (PPh2Ph).
2. Chloro(2-methylphenyl)bis(triphenylphosphine)nickel(II) can be obtained by reacting diphenylphosphine with nickel chloride (NiCl2).
Safety Information:
- Chloro(2-methylphenyl)bis(triphenylphosphine)nickel(II) is relatively stable under normal use conditions, but it still needs to be handled carefully.
-In case of contact, rinse immediately with plenty of water.
-Avoid inhaling dust or contact with skin.
-Wear appropriate protective gloves, glasses and respiratory protection during operation.
-Waste should be handled in accordance with local regulations to avoid pollution to the environment. Chemical waste needs to be properly disposed.